A series of Yanshanian magmatic hydrothermal Cu, Sn polymetal deposits have been reported in Eastern Inner Mongolia Huang Gang-Ganzhuermiao tin and copper polymetallic metallogenic belt, such as Dajingzi, Anle, Maodeng and Aonaodaba. These deposits are mainly hosted in Permian, but the genetic link between Permian and metallogeny is still unknow. Based on our new discovery of sulfide pressure shadow in Permian slate and detailed petrographic and SEM/EDS, in-situ isotopic results, this paper discusses the genesis Permian wall rock in Hongling Pb-Zn-polymetallic deposit and their contribution to Cu, Zn skarn in the area. The results show that the main wall rock of Hongling deposit are Permian marine volcanic and sedimentary rocks. The slate of the deposit has a slightly deformed volcanic origin, and shows pyroclastic texture and with mainly quartz, K-feldspar as the pyroclasts with minor zircon, apatite, ilmenite, and spinel pyroclasts. The cement composited of micro-grained biotite, quartz, K-feldspar, and plagioclase. The pressure shadow comprises a sulfide core and a quartz and chlorite shadow trending along the schistosity of the slate and deformed together with the bedding. The pressure can be crosscut by hydrothermal vein of main ore-stage which shows no fold deformation. The sphalerite and chalcopyrite in the shadow and their similar S isotopic composition (-0.33‰~+1.75‰) with the sulfide in skarn ore implying a contribution of Permian to the mineralization in the area. The results are helpful for understanding the Cu and Zn mineralization in the area and have important guiding to regional exploration.