The basement properties and crustal growth of the Humber belt of Newfoundland Island in the Appalachian orogenic belt, Canada, have been the focus in recent years. In particular, the age composition and isotopic characteristics of the Indian Head Range block in the southwestern part of Newfoundland are significant for dividing and comparing the tectonic attributes of the regional basement. In this paper, the zircon U-Pb dating of the monzogranite pluton in the Indian Head Range block shows that the pluton has a late Mesoproterozoic age (1 149 ±4 Ma), which provides new age evidence for the existence of the Greenville magmatic events in the block. The results of the Nd-Hf isotope study show that the εNd value of the monzogranite is -2.3, the εHf value varies from +1.93 to +3.65, and the t_DM2 age ranges from 1.84 to 1.73 Ga. Combined with previous studies, the authors believe that three stages of granitic magmatic events of~1.5 Ga,~1.15 Ga, and~1.0 Ga occurred in each block in the Humber belt, which have similar Hf model ages, suggesting that they all originated from the reconstruction of Paleoproterozoic juvenile crustal materials. The Greenville basement blocks in the Humber belt are all in-situ basements, and have the same magmatic-tectonic evolution history with the eastern margin of the far end of Laurentian continent. The results of this study provide new constraints on the affinity and crustal growth of the Greenwell basement in the Humber belt, and provide a basis for the traceability and comparison of ancient micro-continents in the Appalachian orogen.