The research on fluid-rock interaction has broken through the rather static solid earth philosophy. Researches in such aspects as the open system, nonequilibrium and kinetics constitute the frontiers of geosciences, with the fluids within the earth's interior as the target. Oxygen isotope exchange reactions in the minerals-fluid system fall imo 5 kinetic models: closed, “closed", unidirectional open fluid-buffered and rock-buffered systems. 18O/16O exchange mechanisms are chiefly diffusion-control and surface-control. The latter is generally accompanied by strong mineralogical alteration, whereas the former lacks such alteration. The granitefluid systems chiefly include the epizonal system, the mesozonal and/or long-lived system as well as the homogenized equilibrium system. The 18O/16O exchange reaction between granite and fluid is mostly ascribed to the open system nonequilibrium type. The essence of syntectonic fluid-rock interaction lies in the coupling of deformation with fluid chemical reactions. Mechanisms of fluid circulation and mass transport comprise mainly advection or infiltration diffusion and composite advection-diffusion.