Time is a basic physical parameter to describe a geological process or geological event. Each radionuclide has a particular half-life, hence, they are applied to investigate different time scales of geological processes according to their half-lives. The occurrence of geological events and the duration of geological processes can restrict their causes and mechanisms, which is the key to reconstruct the geological processes. Currently, many isotope decay systems have been developed to achieve high-precision isotope dating, however, U-Pb chronology system containing double decay system, which is the first tool that precisely restricted the exact age of the earth. From the early solution analysis method to the present in-situ U-Pb geochronology analysis by laser ablation analysis or secondary ion mass spectrometry, U-Pb system has developed vigorously. The only tool for the calibration of all in-situ U-Pb geochronology standards is the double-spike diluent method of thermal ionization mass spectrometry (ID-TIMS). Therefore, this study reviewed the development of high-precision ID-TIMS U-Pb geochronology in detail, where we focused on the milestone events in its development process. Finally, the potential applications of high precision geochronology for ore deposit research are discussed.