The Xinxing lead-zinc (silver) deposit is located in the Tianbaoshan ore concentration area of Yanbian Prefecture, east part of the Xing'an-Mongolia Orogenic Belt. The major orebody is controlled by breccia pipe hosted by the granodiorite intrusion. In order to determine the petrogenetic and metallogenic ages, the material source and the tectonic setting of this deposit, the authors conducted LA-ICP-MS U-Th-Pb dating of zircon grains from the granodiorite related to the mineralization and made geochemical analysis of the intrusion. Zircon grains from granodiorite have the weighted average U-Pb age of 264.6±4.4 Ma(n=15), which means that the rock was emplaced in the middle Permian. The Xinxing granodiorite is characterized by high sodium (Na₂O/K₂O=1.36～1.85, avg.>1), metaluminous nature (A/CNK=0.96～1.04, avg.=0.99), and mid-high Al₂O₃(16.04%～16.34%), similar to features of the arc volcanic rocks, indicating that the metallogenic granodiorite belongs to I-type granite and the high potassium-calc-alkaline series. Most of the samples are strongly enriched in light rare earth elements (LREE)(La/Yb)_N=8.44～16.64, and have low negative Ce anomalies (δCe=0.72～0.91, avg.=0.83) as well as low positive Eu anomalies (δEu=1.00～1.15, avg.=1.06), with the enrichment of such large ion lithophlie elements (LILE) as Ba, Rb and K and incompatible trace elements of Th and U, and relative depletion of high field strength elements (HFSE) such as Ta, Nb and Ti. The ratios of trace elements are between the average value of the crust and that of the mantle, implying the contribution of crust-derived material. In combination with late Paleozoic tectonic evolution of Northeast China, the authors consider that the metallogenic event of granodiorite and related hydrothermal mineralization were caused by the subduction of the Paleo-Asian Ocean Plate in middle Permian. The identification of the magmatic-hydrothermal mineralization event in the area is of great significance for the study of regional mineralization and regional metallogenic regularity.