The inorganic anti-bacterial material of metal ions type is characterized by high security, great anti-bacterial capability, wide working temperature range and heat-enduring properties, and hence it is used in many fields with extensive application value. It consists of two parts, i.e., anti-bacterial metal ions and inorganic carrier materials, and its anti-bacterial properties bear a relationship with the adsorption capacity of metal ions on the carrier material. This paper made a tentative study of two different processes, i.e., the acid modification of sepiolite and sepiolite loading anti-bacterial Zn²⁺, observing the influences of these two means on the structure of sepiolite and the amount of Zn²⁺. AAS, XRD, SEM/EDX, FT-IR were used to characterize the Zn²⁺-loading sepiolite, The results show that the utilization of 5% HCl at the temperature of 70℃ to treat sepiolite is a very necessary and effective means for improving the purity, scattering fiber bundles and expanding the pore space of sepiolite so as to increase the capacity of Zn²⁺-loading. Dry wet cycle way could be employed to enhance the capacity of loading Zn²⁺, but its complex operation and greater energy consumption hinder it from further use. Therefore, an appropriate choice is necessary.