There exists isomorphous replacement in the rutile structure, and the most prominent feature is the average content of oxides, being 1.22%, 0.39%, 0.35% and 0.22% for V 2O 5, Fe 2O 3, ZnO and CuO respectively. They substitute Ti 4+ in octahedra. The valence of V is 5, and its polyhedron is trigonal bipyramid, which causes the lattice distortion, breaks the raw octahedron symmetry into square bipyramid, and produces the microstrains in the structure. TEM study shows the defects in rutile, which can result in the photocatalytic active location. The crashing, heating and microwave radiation can cause the expansion of the lattice volumes, lattice distortion and increase of energy, promoting photocatalystic activity. It is certain that the natural rutile can gestate good photocatalystic activity.