The problems of low hydrophilicity and low specific surface area of natural zeolite lead to its poor humidity control performance, and its large-scale promotion and application are limited. In order to solve this problem, the natural clinoptilolite zeolite in the Weichang area, Chengde, was taken as the research object, and the HNO₃ solution and NaOH solution were used to study the effect of acid/alkali treatment on the structure and humidity regulation performance of natural zeolite and its mechanism. The composition and structure of the material was analyzed using XRF, XRD, TG, FT-IR, N₂ adsorption-desorption technique, and SEM-EDX, etc. The moisture absorption and moisture release properties of the materials were evaluated using different types of saturated salt solutions. The results showed that the acid/alkali treatment could effectively change the composition, structure and moisture controlling properties of natural clinoptilolite zeolite. After alkali treatment, natural clinoptilolite zeolite transformed into Na-P-rich zeolite, the silica-aluminum ratio was reduced from 5.4 to 1.5, the surface hydroxyl content was enhanced by 4.9 times, and the moisture absorption and moisture-release amounts increased by more than 2.64 times and 3.23 times, respectively. After acid treatment, the silica-aluminum ratio of natural clinoptilolite zeolite was raised from 5.4 to 20.5, the surface hydroxyl content increased by 3.5 times, and the moisture-absorption and moisture-release amounts increased more than 1.49 times and 1.46 times, respectively. The alkali-treated zeolite exhibits a broad application prospect in the field of humidity-controlling.