Indium (In), a crucial metal, serves as a significant raw material in the domains of emerging industrial technologies as well as national defense and security. China is one of the most important countries of indium resources in the world, and southeast Yunnan plays the same role in our country. In this paper, the distribution and occurrence of indium in typical deposits such as Zhengcaidong and Laoyingwo in the Puxiong Pb-Zn metallogenic belt at the northern margin of Gejiu granite in Yunnan Province have been studied. LA-ICP-MS in situ trace element test of sphalerite shows that the indium content of sphalerite in Zhenngcaidong deposit ranges from 37.71×10^-6 to 403.88×10^-6, with an average of 157.44×10^-6. The indium content of sphalerite in Laoyingwo Pb-Zn deposit ranges from 378.58×10^-6 to 1 060.08×10^-6, with an average of 631.46×10^-6. The indium content in sphalerite is an order of magnitude higher than that in indium-rich deposits abroad. In addition, many Pb-Zn deposits (occurrences) occur in the Puxiong Pb-Zn metallogenic belt, and sphalerite is the dominate indium-bearing mineral in this region. Therefore, we suggest that the Puxiong Pb-Zn metallogenic belt is also an important indium metallogenic belt, which has important research and utilization values.