The typical characteristics of Sichuan Basin atmosphere are high humidity and weak mobility, where haze is easily formed during the winter and spring seasons. Here, the interactions system of quartz and calcite nanoparticles with toluene and Cr³⁺ in low temperature and high humidity conditions were systematically investigated. Based on the changes in the Zeta potential, colloid size and aggregated morphology, hydrophilic and hydrophobic properties after the quartz and calcite particles coupling with toluene and Cr³⁺, we modeled that:① Since a significant inter-coupling effect between the toluene and Cr³⁺ with quartz and calcite, the presence of toluene and Cr³⁺ can greatly reduce the Zeta potential of quartz and calcite particles in high humidity environment, and results in the instability of quartz and calcite particles at low temperature; ② By its electrostatic force, Cr³⁺ can promote quartz and calcite particles to form agglomerated colloids with larger particle size in high humidity environment; ③ Toluene adsorbed on quartz and calcite particles can enhance their hydrophobicity, and thus weaken the disturbance of water on the stability of quartz or calcite particles-based colloids. The aforementioned findings could provide positive enlightening significance for understanding the mechanism of haze formation in Sichuan Basin from the angle of the inter-coupling of quartz and calcite particles with toluene and Cr³⁺.