The intermediate-acid intrusions in northern Anhui Province of Xu-Su arc were formed by multi-stage magma, and a series of skarn (Fe)-Au-Cu-(Mo) and Fe-Cu deposits related to these intermediate-acid intrusive rocks have been developed. In this paper, the authors studied the zircon U-Pb age of diorite porphyrite which hosts the Wangchang skarn-type iron deposit and Re-Os isotopic age of the molybdenite in the largest skarn-type gold deposit (Yangqiaozi Au-Cu deposit) in this area. The LA-ICP-MS U-Pb weighted age of the Wangchang diorite porphyrite zircon is 132.1±1.9 Ma, and the Re-Os isochron age of the molybdenite in the Yangqiaozi deposit is 130.0±3.2 Ma. The authors systematically summarized the diagenetic age, mineralization type and metallogenic regularity in this area. It is considered that the magmatic rocks in this area can be divided into four stages, and the deposits can be divided into four types. Specifically, the first stage magmatic rocks are early Neoproterozoic mafic intrusive rocks (diabase), which are related to the diamond deposits. The second stage magmatic rocks are intermediate acid intrusive rocks formed in the early Jurassic. The third stage magmatic rocks are the Early Cretaceous intermediate-acid intrusive rocks, which are related to skarn type Fe deposits and skarn type (Fe)-Au-Cu-(Mo) deposits. The fourth stage is late Early Cretaceous acid intrusive rocks. The magmaic Cu-Ni deposits related to mafic intrusive rocks were discovered, but there has been no chronological research reported yet. The Fe and Au-Cu mineralization related to intermediate acid intrusive rocks have been widely developed, but just a few Cu-Ni and diamond mineralizations related to mafic intrusive rocks have been discovered in the in northern Anhui Province of Xu-Su arc. The magmatic rocks in the study area were formed in the extensional structural environment of the North China Craton, but were controlled by different geological events. The large-scale diagenesis and mineralization ages in the area are concentrated in the Early Cretaceous, which was probably related to the destruction of the lithosphere of the North China Craton. The chronological and geochemical data of magmatic rocks and mineralization indicate that there may be a hydrothermal gold polymetallic deposit similar to the Jiaodong area in the deep Xu-Su arc area, which provides a reference for future prospecting in this area.