For the purpose of clarifying the ore-forming fluid and the origin of the lead-zinc-silver-gold deposit, the authors used galena, sphalerite and pyrite for microscopic identification, electron microprobe analysis and ICP-MS analysis. The results show that their consolidation sequence is pyrite, followed by sphalerite (altered pyrite by sphalerite) and galena (altered sphalerite and pyrite by galena). From the spatial distribution of sulfides composition, the authors detected that the migrated pathway of ore-forming fluid was from Diannan-Zhenzigou to Erdaogou-Xiquegou and Dadi-Baiyun, respectively. The formation temperature of sulfides dominated by galena is about 322~327℃ according to the consolidation temperature of galena (327℃) and the uniform temperature of quartz fluid inclusions (322℃). Meanwhile, the sulfide formation temperature of sulfides dominated by sphalerite is about 360~400℃ with reference to the uniform temperature of quartz fluid inclusion (300~360℃), the temperature of chalcopyrite dissolved from sphalerite (>350℃), the temperature of galena-sphalerite formation (344~464℃) using the Cd partition coefficient thermometer in galena-shpalerite and the experimental brittle deformation temperature (about 400℃) of pyrite, but the ore-forming temperature of Ag(Pb-Zn) ore deposits was limited to 390~400℃. Since natural gold mainly occurs in pyrite micro-fractures, the brittle deformation temperature of pyrite (about 400℃) and the temperature of quartz fluid inclusions (230~370℃) constrain the metallogenic temperature of gold to about 370~400℃. The higher metallogenic temperature of Ag(Pb-Zn) and gold deposits may be attributed to the deeper location of the samples collected. At last, the relative relationship between the ore-forming fluid and the Mesozoic (especially the Indosinian period) magmatic rocks was judged by the comparative analysis of trace elements. According to the characteristics of the Indosinian magmatic mixing, it is considered that the magmatic mixing might have contributed to the mineralization in this area.