Several kinds of lead, zinc, silver and copper polymetallic mineralization have been discovered in the Xiangshan uranium orefield during the deep exploration. In this paper, the authors used ICP-MS to determine the content of trace elements of pyrite in the polymetallic mineralization. The results show that the pyrites are rich in Co, Ni, Cu, Zn, Cd, Sb, Tl, Pb and Bi. The LREE/HREE, (La/Yb)_N, Y/Ho, Zr/Hf and Nb/Ta characteristics of pyrites were compared with those of the magmatic rocks and metamorphic basement, and the results show that the ore-forming fluid of polymetallic mineralization was strongly mixed with metamorphic basement materials during upward movement. The LREE enrichment and the low Hf/Sm, Nb/La and Th/La ratios (less than 1) indicate that the ore-forming fluid of polymetallic mineralization was not rich in F and was significantly different from the ore-forming fluid of uranium. The Co content and Co/Ni ratios show that the polymetallic mineralization occurred in a medium-low temperature environment and the ore-forming materials were mainly from metamorphic basement.