The Wang'ershan gold deposit is located in southern Wang'ershan fault belonging to the Jiaojia gold orefield and lies in the western part of Zhaoyuan-Laizhou gold ore belt of Shandong Province. As a large-scale gold deposit, it combines the characteristics of both altered rock type and quartz vein type. Systematic sampling was conducted. The typomorphic characteristics of pyrite and its prospecting significance were discussed. The chemical composition of pyrite is characterized by sulfur depletion and relative enrichment of Au, Ag, Cu, Pb, Zn, As, Co, Ni and Se as trace elements. The occurrence ratio of P-type pyrite is 29.4% in the Wang'ershan deposit. The parameters of thermoelectricity and thermal resistance of pyrites are closely related to gold grade in time and space. The metallogenic temperatures are concentrated in 130.3~339.8℃ according to the thermoelectric coefficient-temperature scale. Cell parameters (a₀ and v₀) and half-peak bandwidth of X-ray diffraction in pyrites are low, with the feature of deep-derived source. δFe-δS plots and lattice parameter a₀ show that the Wang'ershan gold deposit might be a mid-low temperature hydrothermal deposit with relatively serious denudation. It may grade into altered rock type in the deep part.