In order to investigate the impact of different magmatic systems on metallogenic type, the authors studied the petrological and geochemical characteristics of biotite of the granodiorite porphyry from the Wushan Cu deposit in the Middle-Lower Yangtze metallogenic belt and the Zhuxiling W-Mo deposit in Jiangnan orogenic belt. The results show that the biotite of Wushan and Zhuxiling granitoids is magnesium-rich and iron-poor one. Zhuxiling biotite shows relative enrichment of incompatible elements such as Li and Nb, whereas that of Wushan displays high abundances of compatible elements such as Ni and V. Biotite geochemistry shows that these indexes are capable of reflecting A-type, I-type or S-type, oxygen fugacity, and volatile composition of host magma and thus can be used to distinguish different magma sources. Based on biotite geochemistry, the authors established the connection of different petrogenetic and metallogenic systems:the magmatic system in equilibrium with biotite of Wushan Cu deposit shows high Cl, and high oxygen fugacity, which is favorable for Cu mineralization, while the magmatic system of Zhuxiling exhibits higher F and lower oxygen fugacity, which is favorable for W mineralization.