Paleozoic dyke swarms observed in the Qiongheba area of East Junggar are pivotal in understanding the tectonic evolution and setting of this area and even southwestern Central Asian orogenic belt; however, their genesis and tectonic setting are still unclear. In this paper, the authors present observations from outcrop scale to mineral scale, and new mineral chemistry, whole-rock chemistry, zircon U-Pb ages and in situ zircon Hf-O isotope data from the dykes in the Lüshigou pluton of Qiongheba area, East Junggar. On the basis of the new obtained and previously published geochemical and isotopic data, the authors constrained magma sources and petrogenetic processes involved in the generation of these dyke swarms. The dykes in the Lüshigou pluton are composed of diorite-porphyrite and diabase porphyrite. The sensitive high-resolution LA-ICP-MS and SHRIMP U-Pb zircon ages determined for these dykes for the first time indicate that the diorite porphyrite and diabase porphyrite dykes were formed at 346±1 Ma and~332 Ma, respectively. Zircon εHf(t) values of diabase porphyrite dyke in the Lüshigou pluton are from +10.2 to +15.4, with the corresponding two-stage Hf model ages ranging from 0.35 to 0.67 Ga. Zircon δ¹⁸O values mainly vary from 5.00‰ to 6.41‰. These isotope characteristics indicate a mantle source component. Thermobarometric results of amphiboles in the diabase porphyrite dyke indicate that the temperature range varies from 896℃ to 984℃, and pressure range varies from 41 to 88 MPa, with corresponding crystallization depth from~1.54 to 3.31 km. In addition, the result of calculated clinopyroxene-liquid barometer shows that the magma temperature at pyroxene-melt equilibrium is 1 092℃ to 1 099℃ and the pressure is 500 to 630 MPa, so the storage depth of diabase porphyrite magma chamber should be at the depth from 16.5 to 20.8 km. Combined with previously published data, the authors hold that, in the Early Carboniferous, dyke swarms in the Qiongheba area of East Junggar were probably emplaced in a post-collisional setting.