In this study, TiO₂ was loaded onto natural nano mineral chrysotile/leached silica by using hydrolysis of tetrabutyl titanate at room temperature using sol-gel method. The morphological properties and microstructure of the supporters and catalysts at different calcination temperatures were characterized by N₂ adsorption/desorption, scanning electron microscopy (SEM) and X-ray diffraction (XRD). The photocatalytic reactivities of these different catalysts were investigated by UV-assisted degradation of 10 mg/L Rhodamine B. The results show that the TiO₂-loaded silica calcined at 750℃ exhibits significantly excellent reactivity with the removal rate of Rhodamine B up to about 91.57% after irradiation for 40 min, the good adsorption capabilities of the supporters can also contribute to the removal rate of Rhodamine B.