The Niangniangding tungsten-beryllium mining area in Dawu County of Hubei Province is located in the middle of the Tongbai-Dabie orogenic belt between the North China plate and the Yangtze plate. Proterozoic strata outcropped in the area are widespread, magmatic activity is frequent, and the bleak structure is developed, which exhibits a multi-periodic characteristic in the area. The ore deposit occurs along the granite rock contact zone and has close relationship with the late Yanshanian Niangniangding and Jigongshan rock bodies. Based on an analysis of characteristics of metallgonenic geological setting, geological characteristics of the deposit and the two geochemical anomalies in the Niangniangding tungsten-beryllium ore deposit in this area, the paper puts forward the key ore-prospecting orientation, which points to areas of the contact zone between the late Yanshanian granite and strata, rock mass and tectonic fracture zone area. This study not only fills the blank of tungsten-beryllium deposits in Wudang-Tongbai-Dabie metallogenic belt and describes the geological features of beryllium deposit for the first time so as to supply material for the research but also provides a certain theoretical basis and guiding significance for the study area and even for the whole Dabie region so as to help further tungsten-beryllium minerals exploration.