In this study, the authors improved osmosis device on the basis of previous researches. Through the self-made multifunctional osmotic swelling meter in a nitrogen pressure of 1.0 MPa, and under different conditions of content, coefficient of load, compacted density, and water breakthrough time pressing, the authors obtained the permeability coefficient of zeolite-bentonite-pyrite mixture and attapulgite-stone-bentonite-pyrite mixture for two groups of samples. The results showed that the permeability of the integrated backfill material changed little with time, and was basically consistent with Darcy's law. Under the same dry density and water content rate conditions, with the increase of the content of bentonite, the permeability coefficient of different mixed minerals decreased. When bentonite content proportion in zeolite mixture or attapulgite stone minerals was not less than 60%, the permeability coefficient satisfied the requirement of less than 7×10^-10 m/s permeability coefficient in high-level radioactive disposal of backfill material. Under the same conditions, because the zeolite is characterized by non-sticky property, large porosity, and good permeability, the water in the zeolite mixture permeated faster than that of the mixture. In the same dry density and water content rate, the greater the compaction of the loads of different mixtures, the smaller the permeability coefficient, and vice versa. From loads of 50~100 MPa, the permeability coefficient changed little. Thus, the study of the permeability characteristics of the mixture of different ratios and different influence factors, could provide a theoretical basis for the construction of a new type of cushion backfill material in the future.