The Lunlang skarn-type lead-zinc deposit is located in the lead-zinc-silver metallogenic belt on the north side of the Gangdise porphyry copper ore belt. Based on the ore-forming geological conditions, the authors systematically studied the S, Pb isotopic composition characteristics of sphalerite, galena, pyrrhotite and pyrite in the ore, and investigated the sources of the ore-forming materials in comparison with the characteristics of regional mineral resources. It is shown that the δ³⁴S values of the minerals vary in the range of -2.3‰~4.1‰ with an average of -1.46‰, and the δ³⁴S histogram is distributed approximately in a tower shape, which indicates a mantle source. The ²⁰⁸Pb/²⁰⁴Pb ratios are between 38.532 and 39.305 (38.900 on average), the ²⁰⁷Pb/²⁰⁴Pb ratios are between 15.588 and 15.802 (15.687 on average), the ²⁰⁶Pb/²⁰⁴Pb ratios are between 18.179 and 18.692 (18.543 on average), and the μ values are between 9.44 and 9.83, suggesting that Pb was derived from a orogenic belt whose source was composed of the upper crust and the mantle. S, Pb isotopic characteristics of the Lunlang deposit are identical with those of other skarn deposits in northern subbelt of the Gangdise metallogenic belt. The ore-forming materials of the Lunlang deposit was mainly derived from materials of Nyainqentanglha basement gneiss, and partly from the mantle.