The alkali/surfactant/polymer(ASP) flooding technology can significantly enhance oil recovery. Nevertheless, the ASP injection fluid can easily react with reservoir minerals during the productive process which could do harm to reservoir strata and scale, resulting in plugging underground, reduction of the recovery rate and other technical problems. Therefore, the study of dissolution, transportation and plugging process and reaction mechanism of ASP in reservoir becomes a pressing matter of ASP flooding technology. The reaction process of ASP and reservoir minerals including potassium feldspar, quartz and kaolinite and minerals' changing characteristics in the Daqing oilfield were analyzed in detail through some testing means such as X-ray Diffraction(XRD), X-ray Photoelectron Spectroscopy(XPS), Field Emission Environmental Scanning Electron Microscope(ESEM) and Energy Dispersive Spectroscopy(EDS). The study of alkali dissolution reaction kinetics was conducted. And the Si and Al's dissolution kinetics equations of reservoir minerals indicating ions' dissolution and reprecipitation rules were calculated. Finally the reaction mechanism of ASP and reservoir minerals was analyzed. The results show that the dissolved amount of Si in potassium feldspar is three times that of Al after the interaction with ASP for 60 days. Gibbsite and some kinds of silicates are formed. The dissolved amount of Si in quartz increases linearly and exceeds 300×10^-6 after the interaction with pure alkali and ASP for 60 days. Carbonate particles are formed on quartz crystals' surfaces. The dissolved amount of Al in kaolinite is three times that of Si and the crystallinity of kaolinite decreases by 25.26% after the interaction with ASP for 60 days. Gismondine is formed. The corrosion and damage extent of reservoir minerals by alkali is positively correlated with alkali's concentration.