The intermediate-acid magmatic hydrothermal activity in the late Jurassic led to the formation of a Mo-W(Fe)_Pb-Zn-Ag polymetallic metallogenic series in Luanchuan area, western Henan. The Luotuoshan sulfur-zinc polymetallic deposit is located in the contact zone between the rock mass and the strata in the Nannihu orefield. The characteristics of trace elements were studied by using ICP-MS analysis of sphalerite and pyrite based on field geological investigation. Trace element data confirm that the sphalerite from the Luotuoshan deposit is characterized by enrichment of Cd, In and Cu and depletion of Ga and Tl. The dispersed elements such as Cd, In, Ga mainly occur in sphalerite, while Co and Ni mainly occur in pyrite. The values of rare earth elements (∑REE) in sphalerite and pyrite are obviously lower than those in wall rocks. REE of the early stage sphalerite shows a fairly pronounced fractionation and has right-inclined patterns. The REE fractionation is not pronounced, with lower ∑LREE, and the patterns are relatively flat, which shows a opposite trend in the pyrite when it came to the late stage. Some kinds of trace elements like Ga, Ge, Cd, In and Tl can be indicators for metallogenic temperature, ore-forming fluid and genesis. The features of trace elements in sphalerite are closely related to the magmatic hydrothermal activity and suggest that this is a relatively medium-high temperature deposit which is similar to the Zhongyuku deposit in Luanchuan. Ore-forming conditions such as metallogenic temperature exhibit regular variation, as shown by the comparative analysis of the deposits from the proximal part to the periphery of the metallogenic series.