The seal stone is a kind of artwork with historical and cultural characteristics of China. Main mineral components of traditional Chinese seal stone are clay minerals composed of kaolin group and pyrophyllite. Based on a discussion on the mineralization of the seal stone deposits, the authors hold that the deposits were generally formed in the island arc and epicontinental arc tectonic environment and the distribution of deposits were strictly controlled by volcanic apparatus with the ore-bearing wall rocks being Mesozoic intermediate-acid continental volcanics, especially tuffs. The ore-forming material was derived from the wall rocks, and the hydrothermal solution came from the meteoric water. The stability of minerals such as pyrophyllite, kaolinite and sericite depended on the pH, the type of cations and the cation concentration of the aqueous media. A metallogenic model for seal stone deposits has been established in association with the research work of related seal stone deposits.