Following the discovery of the Yulong metallogenic belt and the Gangdise metallogenic belt, the Bangong Co-Nujiang River metallogenic belt is the third metallogenic belt found in Tibet, and the Duolong ore concentration area is a typical ore concentration area in this metallogenic belt. The authors investigated geochemical characteristics, tectonic setting and provenance of granodiorite porphyry by conducting whole rock analysis and Pb-Sr-Nd isotope analysis of Nadun, Bolong, Duobuza, Naruo, Tiegelong and Gaerqin deposits in the NE-trending tectonic belt of this ore concentration area. According to the results obtained, the granodiorite porphyry is mainly of the high K calc-alkaline and shoshonite rock series, with K₂O values being in the range of 2.03%～6.07%; it is enriched in LILE(Rb, K), but depleted in HFSE (Nb, Ta, P, Ti); ∑REE and LREE/HREE values are 48.95×10^-6～249.02×10^-6 and 4.09～21.47, respectively, suggesting the enrichment of LREE; δEu values are in the range of 0.56～1.03, with the average value being 0.78; ²⁰⁸Pb/²⁰⁴Pb, ²⁰⁷Pb/²⁰⁴Pb, ²⁰⁶Pb/²⁰⁴Pb ratios are 38.554～39.419, 15.534～15.665 and 18.465～19.161, respectively, being 38.835, 15.615, 18.659 on average. In the lead isotope diagrams, the granodiorite porphyry is located around the evolution line of the orogenic lead. (⁸⁷Sr/⁸⁶Sr)_i vary in a wide range of 0.705 79～0.711 12, with the average value of 0.707 74. εNd(t) vary in the range of -15.3～-1.7, with the average value of -4.5. Sr and Nd isotope data show that the magma was mixed with the crust and the mantle. In combination with previous researches, the authors hold that the Duolong ore concentration area was formed at the accretionary orogen stage, and its geological setting was an island arc developed on the basis of an accretionary complex, and that the ore-forming materials were derived from the mantle with the addition of crustal material, with the activity conducted by the melt formed by subducting plate. The discovery of the Duolong ore concentration area, the Qingcaoshan deposit and the Xiongmei deposit indicate that more ore deposits are likely to be found in the Bangong Co-Nujiang River metallogenic belt.