The sphalerite oxidative kinetics in hypergene condition was simulated and studied by means of a mixed flow reactor in the pH range of 1.0～7.8, dissolution temperature from 20℃ to 55℃, ferric ion concentration from 1.0×10^-5 to 1.0×10^-2 mol/L, and O₂ flux 0.5 L/min, with ferric ion and O₂ as oxidants. The results indicate that, with ferric ion as the oxidant, the oxidation rate of sphalerite increases with increasing ferric ion concentration, temperature and decreasing pH value, and that, under the conditions studied, the dissolution rates of Zn and Cd are approximately similar to each other, with the activation energy being 41.75 kJ/mol and 42.51 kJ/mol, respectively, which suggests the oxidation rate of sphalerite is controlled by mineral surface chemical reaction. However, with O₂ as the oxidant, the oxidation mechanism of sphalerite varies with the pH value, and its oxidation rate decreases with increasing pH value in the pH range lower than 5.95, whereas the increase of pH value results in a increase of the oxidation rate in the range of pH value greater than 7. The oxidation rate of sphalerite based on double logarithmic dealing with data can be set up.