Located in middle-southern section of the Da Hinggan Ling metallogenic belt, the Huanggangliang Fe-Sn deposit is a typical skarn deposit. In order to determine the petrogenetic and metallogentic ages of the deposit, the authors emphatically studied zircon LA-ICP-MS and molybdenite Re-Os chronology of the granite. Combined with the precise chronological data, this paper discussses in detail the geodynamic setting of the deposit. Zircon LA-ICP-MS analysis of the granite shows that the crystallization age of the granite is 139.96±0.87 Ma, indicating that the granite related to mineralization resulted from magmatism in early Cretaceous period. The molybdenite Re-Os dating gives an isochron age of 134.9±5.2 Ma, which indicates that the metallogentic and petrogenetic ages are consistent with each other. Isotopic chronology demonstrates that both the Huanggangliang Fe-Sn deposit and the associated granite are products of magmatic activities in the Yanshanian period. Combined with ore deposit geology and mineralization epoch as well as regional tectonic evolution, the authors have reached the conclusion that the formation of the Huanggangliang Fe-Sn deposit in the Da Hinggan Ling region occurred at the peak metallogenic stage of 140 Ma. The tectonic setting of the deposit was in the transition period from lithosphere compression to extension.