Zircon U-Pb age, major and trace elements, REE, Sr-Nd-Pb, and zircon Hf isotope compositions were discussed for the Mesozoic Tongjing diorite porphyry in Yinan area of western Shandong Province. The results show that the Tongjing diorite porphyry is characterized by high SiO₂ (54.68%～63.01%) and Mg(Mg^#=55～66) and relatively low TiO₂ (0.2%～0.71%) content, similar to high-Mg diorite distributed extensively in western Shandong Province. There is a strong enrichment of LREE [(La/Yb)_n=10～15] and HFSE (Nb, Ta, Ti) anomaly, with no Eu anomaly, and Sr (241×10^-6～711×10^-6) and Ba (554×10^-6～822×10^-6) content is high. The Sr-Nd isotope characteristics of rock resembling suggest that they have the same magma source. The I_Sr and εNd(t) values are respectively 0.706 473～0.708 867 and -15.13～-9.18, which are not consistent with the data of contemporaneous Yinan gabbro which had been studied by the former researchers. Available isotopic data of the Tongjing diorite porphyry reveal that the major magma sources were enriched lithospheric mantle. Besides, magma from the lower crust and depleted mantle is also important, and Pb isotope shows that the lower crust was formed by North China Craton and Yangtze Craton. Zircon U-Pb age is 128～129 Ma, which is an embodiment of Mesozoic large-scale magmatic activities in east NCC, and the age is similar to that of Mesozoic intursive rock of Jiaodong area, indicating that the two areas might have the same background for magmatic activities. The εHf(t) values range mainly from -13 to -8 with a mean value of -10.3, also implying that the magma came from enriched lithospheric mantle mixed with depleted mantle. The variety of multiple magma sources and the progressive participation of depleted mantle components in response to the lithospheric thinning reached the max in late Mesozoic in the eastern part of North China Craton. The different sources of magma might have been the main factor responsible for mineralization between Jiaodong peninsula and western Shandong Province.