Lots of granitoids are distributed in Tengchong-Lianghe area, western Yunnan Province. According to data available, the ages of these granitoids are mostly concentrates in the Late Mesozoic-Cenozoic period. In this paper, ages of Late Permian-Middle Triassic peraluminous granites in this area were obtained for the first time. Granitoid bodies are distributed near southeastern Lianghe County. The major rock types include mainly grayish medium-grained two-mica granite and subordinately gray fine-grained two-mica granite in the form of bosses or dikes one to several meters in width scattered in medium-grained two-mica granite. The medium-grained two-mica granite exhibits hypidiomorphic granular texture and is mainly composed of K-feldspar (perthite，±40％), quartz （±30％）, plagioclase (oligoclase，±15％), biotite and muscovite（±15％）, with accessory minerals comprising zircon and iron oxides. The fine-grained two-mica granite exhibits hypidiomorphic granular texture too and is mainly composed of K-feldspars (perthite and microline, ±30％), quartz （±25％）, plagioclase (oligoclase, ±25％), biotite and muscovite（±20％）, with accessory minerals being zircon and magnetite. The two-mica granites have the following geochemical characteristics: SiO2＝69.74%～74.44%, Al2O3=13.91%～14.52%, MgO=0.26%～0.87%, CaO=0.72%～1.36％, K2O=5.24%～5.78%, Na2O=2.63%～2.82%, K2O/Na2O=1.87～2.20, and Al index (A/CNK)＝1.11～1.20. Moreover, corundum can be found in the CIPW norm minerals, which possesses some features of strongly peraluminous granites. The two-mica granites composed of medium-grained and fine-grained granite are characterized by the enrichment of Rb（315×10-6～452×10-6）, U（7.68×10-6～11.2×10-6）and Th（15.2×10-6～111×10-6）. Primitive mantle-normalized element concentration patterns of both granites show remarkable negative anomalies of Ba，Nb，Sr，P，Ti. Likewise, both of the granites display similar REE patterns: Eu/Eu*=0.25～0.47 and (La/Yb)N =6.53～34.06. Most of the zircons from the sample show oscillatory zoning in CL images with Th/U ratios from 0.1 to 1.8, indicative of magmatic zircon in genesis. Zircon LA-ICP-MS U-Pb dating from the same sample yielded concordant ages of 256.0 ±5.6 Ma (MSWD=4.1) and 234.2 ±3.1 Ma (MSWD=5.6), which respectively indicate the early (i.e. Late Permian) and late (i.e. Middle Triassic) magmatic episodes during the early Indosinian period in this area. An inherited zircon age（ca.596 Ma）was also obtained. In-situ Hf isotopic analyses yieldedεHf(t) values of -8.5 to +1.3, corresponding to the Hf isotopic crustal modal ages (tDMC) of 1195～1815 Ma. The geochemical signatures and zircon Hf isotopic compositions suggest that the magma of the two-mica granites was dominantly derived from partial melting of clay-rich psammite in the older crust. These two-mica granites were formed in a continental collision environment. Combined with available data, it is held that the generation of the collisional strongly-peraluminous granite in the Late Permian-Middle Triassic period suggests an orogenic event during early Indosinian in the Sanjiang Paleo-Tethys Sea. The Sanjiang early Indosinian orogenesis was intimately related to the closure of the Paleo-Tethys Sea and the subsequent orogenic events.