Both mineral granules and microorganism individuals are important components of atmospheric particulate matter (PM), having high relationship in morphology, association and aerodynamic behaviors. This paper has expounded the granule characteristics, free radical and biological activity as well as the effect of interaction between IP, IMG and microorganisms and pointed out the importance of the interaction between atmospheric particles and microorganisms. In future, the emphasis of the study should be placed on environmental chemistry and microorganism behaviors, the size effect and boundary film effect in the near size effect system of the IMG_microorganism system on surface morphology, surface electrical property, surface group and free radical of mineral particles, the relationship of the secretion of protein to the phase transition, the element variable valence and the solution (complexation) as well as the diversification of particle activity and biological toxicity caused by these factors.