Biomineralization in the cardiovascular system of the human body is mainly characterized as calcifications with the formation of calcium phosphates, which are commonly composed of the valvular heart as well as aortic and coronary artery calcifications. Based on calcification features of the cardiovascular system and the medicinal understanding in this aspect, this paper focuses on the relationship between the cardiovascular calcification and the disease diagnosis and treatment with the purpose of developing a new method for the early diagnosis and treatment of the cardiovascular calcification from the angle of the cross discipline of mineralogy and pathology.