Being important in such geological processes as crystallization, dissolution, alteration, mineralization and weathering and applied widely to environmental science and material science, the surface reaction of minerals has recently become a geological focus in the world. Based on analyzing the research advances in surface reaction of sulfide minerals, this paper points out that there are problems which have not yet been solved in the study of pyrite dissolution. However, pyrite dissolution is of great significance in many fields such as (1) the theoretical importance (e.g., how is S 2- _2 transformed into S 2- ? How are the charges balanced when S 2- _2 is transformed into S 2- ?), (2) the significance in evaluating mining environment, (3) the phenomenon that most of pyrite in tailing is under the reductive acidic condition, and (4) the control of the dissolution of pyrite over the cycle of sulfur in the ocean. Furthermore, the primary kinetic results from the experiment of pyrite dissolution are also reported in this paper.