The dissolving characters and bio_resistance of 6 pairs of mineral dusts in a simulated human body environment for 96 days were studied by using Gamble solution and three acid series. The results show that the iron dissolving rates in most mineral dusts have two peaks, and that magnesium is dissolved simultaneously with iron in dusts with tri_octahedral structure. Most of the dissolving rates of high_magnesium mineral dusts display peaks in the first dissolving stage. The calcium dissolution rates of zoelite and wollastonite are relatively stable, and wollastonite show the feature of being high in the front and low in the rear in the low_pH area. The dissolution peak of Si appeared in the first 48 days in Ph5 Gamble solution, but after 48 days in the pH7 series. Al dissolution is easy in the pH3 and pH5 series and difficult in pH7. The cumulate dissolution amount of all elements in Gamble solution of fibrous mineral dusts increases with time, and the total dissolution amount of fibrous samples is mostly larger than that of the clayey ones. There are phenomena of cracking, etching and peeling on the surface of fibrous minerals and fibers tend to be scattered or break during dissolution. The dissolving rate of flaky dusts is positively correlated to the step densities and oxidizing rate of iron_bearing samples. The total dissolution amount is basically positively proportional to the system acidity and total organic ions. The dissolving rate of Ca-, Mg- or Al-rich mineral dusts is higher than that of K- or Si_rich dusts. The low pH, high solubility of O2 or oxidizing reaction and high salinity solution of the environment may accelerate the dissolution of dusts.