A method for sequential determination of gas and liquid contents in mineral inclusions at ppbppm level by gas-ion chromatography is described. Gases of H20, CO2, H2, O2, N2. CH4, CO etc and ions of F-，C1]-，NO3- ,SO4(2-), Li+, Na+,NH4+ ，K+ etc. in liquid phase can be quantitatively determined using 0.500 g sample. The method is sensitive and simple. The variation coefficient is less than 5% for gas phase and 2% for liquid phase.