In the process of ore prospecting prediction, basic geological big data has a significant impact, resulting in poor accuracy of screening results when applied to complex geological areas. Therefore, a remote sensing prospecting prediction method for Pengshan ore field in De'an County, Jiangxi Province was studied. As a typical ore field in the Pengshan area, the Xiabianshan tin ore area is analyzed for its geological characteristics and mineralization rules. Based on the analysis results and remote sensing technology, remote sensing prospecting elements and remote sensing alteration information are obtained. A remote sensing comprehensive information prospecting target area prediction model is established, and the quantitative prediction results of the prospecting target area in the Pengshan area are obtained. The prediction results show that three typical prospecting target areas have been quantitatively predicted in the study area, located on the northwest, west, and east sides of the area, mainly consisting of annular and banded structures, and the structural development directions are mainly northeast, northwest, and nearly south-north. The remote sensing alteration information extracted mainly includes carbonation, epidotization, chloritization, sericitization, kaolinization, and iron staining. All three target areas have good mineralization conditions. The field investigations have confirmed the existence of kaolinization, iron staining and carbonation in the three target areas, and the contents of Cu and Au in the altered rock blocks are high. The predicted results have been confirmed, providing reliable reference for ore prospecting in this area.