The north Wuyi area in Jiangxi Province is located on the southern side of the Pingxiang-Guangfeng junction zone on the Qinhang mineralization belt. Multiple tectonic events and magmatic activities formed a complex geological structure pattern in this area, and metallogenic potential of copper and lead-zinc polymetallic deposits is enormous. However, due to the generally small scale and insufficient research of lead-zinc deposits in the northern Wuyi area of Jiangxi Province, there is a lack of in-depth understanding of material sources, metallogenic conditions, and deposit genesis. This paper takes Laohudong Pb-Zn deposit in the northern Wuyi area of Jiangxi Prov-ince as the research object. EPMA, LA-ICP-MS and LA-MC-ICP-MS were used to reveal the major and trace element and sulfur isotope composition of sulfides, then many important information concerning the mineralization temperature, the source of metallogenic materials and the genesis of the deposit were investigated. EPMA testing shows that the Fe content in sphalerite ranges from 7.58% to 8.27%. Combined with LA-ICP-MS trace element testing, sphalerite is rich in Fe, Mn, Cu, Cd elements, followed by Co, Ni, Ag, In and Pb elements, the contents of Ga, Ge, As, Se, Sn and Bi elements are low. In sphalerite, Mn, Fe, Cd, In and Co exist in the form of isomorphism,while Cu, Ag, Pb exist in the form of isomorphism and microscopic inclusions. The content of Fe, the values of Ga/In (0.001~0.129), Zn/Cd (262~312) and calculation results of relevant formulas of sphalerite all indicated that sphalerite was formed under medium to high temperature mineralization conditions (about 327~337℃). The δ³⁴S of sphalerite and pyrite respectively concentrated between 2.07‰~4.16‰ and 0.82‰~3.19‰,they all indicated magmatic sulfur. Compared with multiple Pb-Zn deposits in China, the trace element composition of sphalerite in Laohudong Pb-Zn deposit is consistent with typical skarn deposits. The Laohudong Pb-Zn deposit has a close genetic relationship with the Gexianshan granite complex, and the age of Gexianshan granite complex (153.9±2.7 Ma and 162.8 ± 1.2 Ma) can represent the lower limit of the mineralization time, which is consistent with the range of the main polymetallic Pb-Zn deposits in the north Wuyi area.