In the magma-related deposits, the ore-forming plutons generally experienced high-degree evolution and differentiation, so its petrologic and geochemical characteristics can only reflect the final state of magma evolution. The evolution of ore-hosted magma and the geochemical behavior of main metallogenic elements in the evolution remain unclear. However, the study of contemporaneous and sympatric magmatic rocks provides a potential solution for this question. Here the authors made a case study of the northern Gangdise Pb-Zn ore belt in Tibet formed in the early period of continental collision. Based on the statistical study of lots of published geochemical analyses of magmatic rocks from the Gangdise belt, this paper presents the evolution of magma and its control of metallogenesis. The results suggest that, besides the crystallization differentiation of magma itself, crustal contamination was another factor controlling the evolution from basic magma to acid magma during differentiation. It is also found that most of the magmatic rocks formed in the early period of continental collision are less oxidized and less hydrous; nevertheless, when magma evolved to the middle and late period, the oxidation of magma increased with progressive evolution. Mantle-derived magmas are enriched in S and H₂O, which experienced underplating at the base of Zn-enriched crust materials and induced partial melting. Crust-derived magmas experienced high-degree evolution, and finally resulted in the formation of the northern Gangdise Pb-Zn ore belt.