To explore the stabilization effect of palygorskite activated by different concentrations of H2SO4 solution on Cd in soil, the authors carried out acid activation of palygorskite by using H2SO4 solutions with concentrations of 5%, 7.5%, 10%, 12.5% and 15%, respectively. Stabilization experiments and pot experiments were carried out with the addition of Cd contaminated soil. The results showed that the active Cd content of soil was significantly reduced by applying palygorskite activated by different concentrations of H2SO4 solution, and that the stabilization effect of 10% H2SO4 activated palygorskite was the most significant. The extracted Cd content of toxic leaching (TCLP) and diethylene triamine pentacetic acid (DTPA) decreased by 31.11% and 37.33%, respectively. The results of continuous extraction by the European Community Reference Agency (BCR) showed that palygorskite modified by acid can significantly reduce the content of acid-soluble state and reduction state of Cd in soil. The palygorskite modified by acid could significantly inhibit the absorption of Cd in soil and the transfer of underground part to the aboveground part. The content of Cd in the surface part of maize decreased by 26.99%~43.97% compared with the control group, and the content of Cd in the underground part of maize decreased by 15.36%~27.40% compared with the control group. Palygorskite modified by acid has obvious stabilization effect on Cd in soil.