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正常菌与可吸入矿物细颗粒作用致突变性研究
A study of the mutagenicity of normal bacteria interacted with inhalable mineral granules
投稿时间:2017-08-30  修订日期:2017-10-18
中文关键词:可吸入矿物细颗粒(IMG)  Ames试验  表皮葡萄球菌  大肠杆菌  致突变性
英文关键词:inhalable mineral granules (IMG)  Ames test  Epidermis staphylococcus  Escherichia coli  mutagenicity
基金项目:国家自然科学基金重点项目(41130746);国家自然科学基金面上项目(41472046)
作者单位E-mail
马骥 四川绵阳四○四医院检验科, 四川 绵阳 621000  
董发勤 西南科技大学, 四川 绵阳 621010  
邓建军 四川绵阳四○四医院检验科, 四川 绵阳 621000 jianjundeng0801@163.com 
曾娅莉 四川绵阳四○四医院检验科, 四川 绵阳 621000  
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中文摘要:
      采用Ames试验分别对蒙脱石、石英、方解石、钠长石4种可吸入矿物细颗粒及其与大肠杆菌、表皮葡萄球菌相互作用48 h后的混悬液作为受试物进行检测,分析IMG是否具有致突变性,及其与人体正常细菌群作用后,IMG/正常菌复合体是否有致突变性毒力改变。结果显示石英以及石英/大肠杆菌复合体对TA98、TA100菌株Ames试验呈阳性反应;石英/表皮葡萄球菌复合体对TA98菌株Ames试验呈阳性反应;而蒙脱石、方解石、钠长石纯矿及其与正常菌作用后的复合体Ames试验结果均为阴性。结果表明石英具有直接致突变作用;石英与正常菌菌作用后复合体依然具有致突变性,但石英表现出的碱基置换突变作用在与表皮葡萄球菌作用后消失,其机制有待进一步研究。
英文摘要:
      The mutagenicity of inhalable mineral granules (IMG) and interaction with Epidermis staphylococcus, E. coli were studied by Ames test to analyze whether IMG and IMG/body normal flora complex has mutagenicity. The results show that Ames test of the quartz and quartz/E. coli complex on TA98 and TA100 strains assumes positive reaction, Ames test of quartz/epidermis staphylococcus complex on TA98 strains assumes position reaction, whereas Ames test of montmorillonite, calcite, albite and complex from interaction with body normal flora exhibits negative reaction, which suggests that the quartz has direct mutagenic effect, quartz/body normal flora complex still has mutagenicity, but the mechanism of the phenomenon that base replacement mutation effects of quartz disappeared after interaction with Epidermis staphylococcus needs further research.
马骥,董发勤,邓建军,曾娅莉,2017,正常菌与可吸入矿物细颗粒作用致突变性研究[J].岩石矿物学杂志,36(6):903~908.
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